Colorectal cancer: clinicohistopathological study at tertiary care hospital in Western Maharashtra

  • Dr Sunil Vitthalrao Jagtap Department of Pathology, Krishna Institute of Medical Sciences University Karad, Maharashtra India.
  • Dr Wasim Khatib Lecturer, Department of Pathology, Krishna Institute of Medical Sciences University Karad, Maharashtra India.
  • Dr Atul Hulwan Assistant Lecturer, Department of Pathology, Assistant Lecturer, Department of Pathology, Krishna Institute of Medical Sciences University Karad, Maharashtra India.
  • Dr Swati S. Jagtap Associate Professor Department of Physiology, Krishna Institute of Medical Sciences University Karad, Maharashtra India.
  • Dr S.R. Kulkarni Department of Surgery, Krishna Hospital and Medical Research Center Karad, Maharashtra, India.
Keywords: Colon cancer, Adenocarcinoma colon, Histopathology colon

Abstract

Aims and objectives: To study the clinicopathological features of primary colorectal cancer and classify it on histopathology and grading of tumor. Materials and

Methods: This is retrospective, descriptive, analytical study carried out in the department of pathology at tertiary care hospital in Western Maharashtra. The study period was 5 years from May 2008 to April 2013.

Result: A total of 217 cases of colorectal lesion were studied. Among these 73 cases (33.64%) were of non-neoplastic lesion, 19 cases (8.75%) were of benign, 125 cases (57.60%) were of colorectal malignancies. The rectum was commonest site of involvement by tumor. Maximum number of cases were observed in the age group of 61-70years of age (27.3%) with slight male predominance (M:F- 1.1:1). Bleeding per rectum was frequently seen clinical manifestation. Left sided colonic malignancy cases were common-89 cases / 125 (71.2%). The most common malignancy was adenocarcinoma which constitute 96 cases (76.8%) followed by mucinous adenocarcinoma 12 cases (9.6%), Signet cell adenocarcinoma 4 cases (3.2%). Among the 96 cases of adenocarcinoma grade I were 36 cases (37.89%), Grade II were 50 cases (52.08%), and grade III were 10 cases (10.52%).

Conclusion: This study shows colorectal cancer is not an uncommon in this geographic region. The patients were presented at later age, left sided colonic malignancies were more. Bleeding per rectum is frequently seen clinical manifestation. Adenocarcinomas constitute (76.8%) as most common histological type with maximum cases in grade II (52.08%). This analysis suggests the need for patient awareness of this common cancer. Regular mass screening program to be implemented which will help for early detection and treatment of CRC.

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References

1. Parkin DM, Whelan SL, Ferlay J, Raymond L & Young J. Cancer Incidence in Five Continents. (IARC Scientific Publications No. 143), Lyon, International Agency for Research on Cancer; 1997: 566-7.

2. National Cancer Registry Program. Population based cancer registries 2004-2005. New Delhi ICMR; 2008.

3. World Cancer Research Fund and American Institute for Cancer Research Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global perspective. Washington, DC: American Institute for Cancer Research; 2007.

4. Parkin DM. International variation. Oncogene. 2004 Aug 23;23(38):6329-40.

5. Boyle P, Langman JS. ABC of colorectal cancer: Epidemiology. BMJ. 2000 Sep 30;321(7264):805-8.

6. Jessup JM, McGinnis LS, Steele GD Jr, Menck HR, Winchester DP. The National Cancer Data Base. Report on colon cancer. Cancer. 1996 Aug 15;78(4):918-26.

7. Moore MA, Ariyaratne Y, Badar F, Bhurgri Y, Datta K, Mathew A, Gangadharan P, Nandakumar A, Pradhananga KK, Talukder MH, Yeole BB, Sobue T. Cancer epidemiology in South Asia - past, present and future. Asian Pac J Cancer Prev. 2010;11 Suppl2:49-66.

8. Singh PN, Fraser GE. Dietary risk factors for colon cancer in a low-risk population. Am J Epidemiol. 1998 Oct 15;148(8):761-74.

9. Willett WC, Stampfer MJ, Colditz GA et al. Relation of meat, fat and fibre intake to the risk of colon cancer in a prospective study among women. N Engl J Med. 1990;323(240:1664-72.

10. Slattery ML, Potter J, Caan B et al. Energy balance and colon cancer beyound physical activity. Cancer Res 1997;57(1):75-80.

11. Ayyub MI, Al-Zadi AO, Khazindar AM, Nagi AH, Massiyar IA. Clinicopathological trends in colorectal cancer in tertiary care hospitals. Saudi Med J 2002; 23: 160-3.

12 Mahmood Q, Masood I A, Siddique N. Colorectal Carcinoma; Frequency in southern Punjab. Professional Med J. 2006;13(2):192-200.

13. Kenneth R, McQuaid MD. Current medical diagnosis and treatment. In : Tierney LM, McPhee SJ, Papadakis MA. Editors.Lange medical books. 43 rd edition New York.McGraw- Hill 2004. P- 613.

14. Ries LAG, Melbert D, Krapcho M et al. SEER cancer statistic review 1975-2005. Bethesda MD. 2008.

15. Mohsin- ul-Rasool, Basharat M, Riyaz-u-Saif A et al. Histopathological study of neoplastic lesions of large intestine in Kashmir valley, India. Int J Res Med Sci
2014; 2(3): 1097-1100. doi: 10.5455/2320-6012. ijrms 20140890

16. Aljebreen AM. Clinicopathological patterns of colorectal cancers in Saudi Arebia: Younger with an advanced stage presentation. Saudi J Gastroenterol 2007; 13:84-7. DOI: 10.4103/1319-3767.32183

17. Javid G, Zargar SA, Rather S, Khan AR, Khan BA, Yattoo GN, Shah A, Gulzar GM, Sodhi JS, Khan MA, Bashir AS. Incidence of colorectal cancer in Kashmir valley, India. Indian J Gastroenterol. 2011 Feb;30(1):7-11. doi: 10.1007/s12664-010-0071-7.Epub 2011Feb 12.

18. Jass JR, Sobin LH. Histological typing of intestinal tumours. In: WHO International Histological Classification of Tumours, 2nd, Springer-Verlag, Berlin-New York 1989.

19. National cancer registry programme, consolidated report of hospital based cancer registries 2001-2003. 2007: 125-126.

20. Jemal A,Clegg L X, Ward E, et al.Annual report to the nation on the status of cancer,1975-2005,with a special feature regarding survival. Cancer, 2004;101, 1:3-27. DOI: 10.1002/cncr.20288

21. Sushama Desai, Sunil Jagtap, Hemant Janugade. Coexisting Tuberculosis And Mucinous Carcinoma Of Caecum – A Case Report. Medical Journal Armed
Forces India-MJAFI 2005; 61 : 197-199.
Published
2016-06-30
How to Cite
Dr Sunil Vitthalrao Jagtap, Dr Wasim Khatib, Dr Atul Hulwan, Dr Swati S. Jagtap, & Dr S.R. Kulkarni. (2016). Colorectal cancer: clinicohistopathological study at tertiary care hospital in Western Maharashtra. Biomedical Review: Journal of Basic and Applied Medical Sciences (JBAMS), 3(2), 37-41. Retrieved from https://biomedical.medresearch.in/index.php/jbams/article/view/33
Section
Original Article